Home > "Nano and SPR" opens a new era of anti-cancer

"Nano and SPR" opens a new era of anti-cancer

Edit: Ccdanni 2020-02-11 Mobile

  In 1983, Liedberg et al. Used surface plasmon resonance technology for the first time to analyze the antigen-antibody interaction, which resulted in the world's first SPR biosensor, and this technology was applied to the field of biosensors. For more than 30 years, SPR technology has been widely used in various fields such as biology, medicine, chemistry and environmental science. SPR technology has its unique advantages, namely high sensitivity; no labeling required; it can maintain the biological activity of the molecule; it can obtain real-time kinetic data of the reaction; fast response; fast detection process; convenient operation. Based on these characteristics, the SPR sensor has become the most valuable One of the potential biosensors. However, there are few reports in China to detect tumor markers. If SPR technology can be used for early detection, early diagnosis, and early treatment, it is bound to greatly improve the survival rate of cancer patients and make a certain contribution to early warning of cancer.

  

  The resonance angle or resonance wavelength of SPR is closely related to the properties of the surface of the metal thin film. The surface plasmon resonance angle of different dielectrics is different. The amount of the same dielectric attached to the metal surface is different, so the response intensity of SPR is different. SPR biosensors based on this principle usually immobilize a molecule with specific recognition properties, that is, ligand A, on the surface of a metal membrane, and monitor the binding process of analyte B in solution with the ligand. During the formation or dissociation of the complex, the refractive index of the solution on the surface of the metal film changes, which can be detected by the SPR biosensor in real time. Due to the strong specificity, high sensitivity, and repeatability of antigen and antibody responses, the mutual recognition process of antigens and antibodies is always the most common detection object of SPR biosensors. With the rapid development of science, SPR technology is gradually applied to the monitoring of the interactions between various biological macromolecules such as DNA and protein, protein and protein, drugs and protein, nucleic acid and nucleic acid, receptor and ligand, and the technology With real-time analysis, simple and fast features and advantages, SPR biosensors are currently widely used in biomolecular interactions, drug screening, food detection, and environmental monitoring.

  As a new modern analysis method, SPR technology has its unique advantages. In recent years, with the continuous improvement of SPR instruments, its development has been very rapid, and it is expected to make a certain contribution in the early warning of cancer. Applications in this area include early detection of tumor markers and screening of anti-cancer drugs. Now SPR technology has been used to detect tumor markers for a series of cancers including lung cancer, cervical cancer, prostate cancer, breast cancer, colon cancer and ovarian cancer. This application of SPR technology is useful for the early detection, early diagnosis, Treatment is of great significance.

  After nearly 30 years of development, SPR biosensors have become an indispensable research tool in life sciences, medicine and other related disciplines. Compared with traditional analysis methods, it has many unique advantages that are unmatched by other analysis methods, and with the continuous development of computer technology, SPR technology is still being improved. SPR technology not only has a good development space and prospect in the detection of tumor markers, but also has a good development trend in the screening of new anti-cancer drugs. If SPR technology can be applied to these two aspects, early warning of human cancer will be just around the corner.

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